The evolution and international spread of extensively drug resistant Shigella sonnei
Authors:
Mason L, Greig D, Cowley L, Partridge S, Martinez E, Blackwell G, Chong C, De Silva M, Bengtsson R, Draper J, Ginn A, SandaraduraI, Sim E, Iredell J, Sintchenko V, Ingle D, Howden B, Lefevre S, Njamkepo E, Weill F, Ceyssens P, Jenkins C, Baker K
Abstract:
Shigella sonnei causes shigellosis, a severe gastrointestinal illness that is sexually transmissible among men who have sex with men (MSM). Multidrug resistance in S. sonnei is common and can include resistance to the World Health Organisation recommended treatment options, azithromycin, and ciprofloxacin. Recently, an MSM-associated outbreak of extended-spectrum β-lactamase producing, extensively drug resistant S. sonnei was reported in the United Kingdom. Here, we aimed to identify the genetic basis, natural history, and international dissemination of the outbreak strain. Our genomic epidemiological analyses of 3,304 isolates from the United Kingdom, Australia, Belgium, France, and the United States of America revealed an internationally connected outbreak with a common, low fitness-cost resistance plasmid, previously observed in travel associated sublineages of S. flexneri . Our results highlight the persistent threat of horizontally transmitted antimicrobial resistance and the value of continuing to work towards early and open international sharing of genomic surveillance data.
Journal:
Research Square