Pathogens: exploiting recent advances in genomics
The aim of this research theme is to develop the analysis of whole genome sequence of gastrointestinal pathogens for improved surveillance and investigation of infectious intestinal disease. A major objective is to provide a comprehensive integrated analysis platform comprising WGS data and associated metadata data to facilitate the evidence-based interpretation of genomic variation to test biological and epidemiological hypotheses.
Further objectives include the investigation of archival specimens held by the PHE to develop improved algorithms for responding to outbreaks of infectious disease, and the generation of well annotated publicly available genome sequence databases. The work will complement and enhance current research and development work in PHE and Oxford, strengthening and extending on-going collaborations.
Professor Martin Maiden
Professor of Molecular Epidemiology, University of oxford
Dr Kathie Grant
Head Gastrointestinal Bacteria Reference Unit, GBRU, Public Health England